Faculty

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Dr. Pravin Rameshwarji Bhansali

Professor

Department of Science

Dr. Pravin Rameshwarji Bhansali completed his postdoctoral research at Johns Hopkins University, USA, a premier research institute in the world where he worked on National Institute of health (NIH) USA funded projects related to antibacterial and anticancer therapy. Dr. Bhansali completed his Ph.D. in Medicinal and Biological Chemistry from the University of Toledo, Ohio, USA and holds an M.Pharm. Degree in pharmaceutical chemistry from Bharati Vidyapeeth’s Poona College of Pharmacy, Pune.

During his doctoral thesis, Dr. Bhansali worked on total synthesis of largazole, a natural potent and selective anticancer agent which inhibits histone deacetylase (HDAC) enzyme.

His research interests include medicinal chemistry and drug design development.

  • Pravin Bhansali, Cristin Hanigan, Robert Casero, Viranga Tillekeratne, “Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation.” Journal of Medicinal Chemistry, 2011 Nov 10; 54 (21), 7453-63
  • Salahuddin Ahmed, Sharayah Riegsecker, Maria Beamer, Ayesha Rahman, Joseph V. Bellini, Pravin Bhansali, L.M. Viranga Tillekeratne, " Largazole, a class I histone deacetylase inhibitor, synergizes with TNF-α to induced ICAM-1 and VCAM-1 expression in Rheumatoid Arthritis synovial fibroblasts " Toxicology and Applied Pharmacology, 2013 July 15; 270 (2), 87-96
  • Stephen Zano, Pravin Bhansali, Amarjit Luniwal, Ronald E. Viola, “Alternative Substrates for S-adenosylmethionine Synthetases from Infectious Microorganisms” Archives of Biochemistry and Biophysics, 2013 August 1, 536 (1) 64-71
  • Pravin Bhansali, Cristin Hanigan, Lalith Perera, Robert Casero, Viranga Tillekeratne, “Synthesis and Biological Evaluation of Largazole Analogues with Modified Surface Recognition Cap Groups” European Journal of Medicinal Chemistry, 2014 October 30, 86, 528–541 v. Alexander G. Pavlovsky, Bharani Thangavelu, Pravin Bhansali, Ronald E. Viola; “A Cautionary Tale of Structure-guided Inhibitor Development against an Essential Enzyme in the Aspartate Biosynthetic Pathway” Acta. Cryst. (2014), D70, 3244-3252
  • Mojun Zhao, Yasanandana S. Wijayasinghe, Pravin Bhansali, Ronald E. Viola, and Robert M. Blumenthal, “A Surprising Range of Modified-Methionyl S-Adenosylmethionine Analogs Support Bacterial Growth” Microbiology, 2015 March;161(Pt 3), 674-682
  • Bharani Thangavelu*, Pravin Bhansali*, Ronald E. Viola; “Elaboration of a Fragment Library Hit Produces Potent and Selective Aspartate semialdehyde Dehydrogenase Inhibitors” Bioorganic & Medicinal Chemistry, 23, (2015), 6622-31. Equal authorship
  • Pravin Bhansali, Viranga Tillekeratne, “Efforts of medicinal chemists to develop and drug design aspects of HDAC inhibitors” Review in preparation
  • Pravin Bhansali, Ronald E. Viola; “Synthesis of L-methionine analogs with varying structural modifications for quorum sensing inhibition” In preparation
  • Yasanandana Supunsiri Wijayasinghe#, Pravin Bhansali#, Ronald E. Viola, Mohammad A. Kamal and Nitesh Kumar Poddar, “Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19” Accepted by Current Pharmaceutical Design; DOI: 10.2174/1381612826666201118111151 # Equal authorship xi. Pallavi Sharma; Arti Tyagi; Pravin Bhansali; Vineeta Singh; Shubra Pareek; Nitesh Poddar, “Saponins: Extraction, Bio-medicinal Properties and way forward to Anti-viral representatives” Food and Chemical Toxicology; Volume 150, April 2021, 112075 (Elsevier Publications)

Representative Posters:

  • April 2014 Sharayah Riegsecker, Wylie Wingerter, Anil K. Singh, Pravin Bhansali, L. M. Viranga Tillekeratne, Salahuddin Ahmed, “Epigenetic regulation of IL-6 by pro-inflammatory cytokines in rheumatoid arthritis synovial fibroblasts: role of HDAC inhibitors” Experimental Biology, San Diago, USA
  • June 2013 Salahuddin Ahmed, Sharayah Riegsecker, Ayesha Rahman, Maria Beamer, Joseph Bellini, Pravin Bhansali, L. M. Viranga Tillekeratne, “Largazole, a class I histone deacetylase inhibitor, enhances TNF-α-induced ICAM-1 and VCAM-1 expression in Rheumatoid Arthritis Synovial Fibroblasts” Rheumatology Research Workshop, Dallas, USA
  • Apr 2013 Jehad S Almaliti, Pravin Bhansali, Christin L. Hanigan, Robert A Casero Jr, L. M. Viranga Tillekeratne. “Design, synthesis, and biological evaluation of novel Largazole analogs with modified surface recognition cap groups targeting histone deacetylases” 245th ACS National Meeting and Expositions, New Orleans, USA
  • Aug 2012 Jehad Almaliti, Pravin Bhansali, Christin L. Hanigan, Robert A Casero Jr., L. M Viranga Tillekeratne. “Synthesis and Biological Activity of Largazole Analogues Targeting Histone Deacetylases” 244th ACS National Meetings and Expositions, Philadelphia, USA
  • 2010 Pravin Bhansali, Viranga Tillekeratne. “Synthesis of Analogs of Largazole: A Potent Anticancer Agent” 2010 FIP Pharmaceutical Sciences World Congress /AAPS Annual Meeting and Exposition, New Orleans, USA
  • 2010 Pravin Bhansali, Viranga Tillekeratne. “Largazole analogs with modified zinc interacting moiety” 240th ACS National Meetings and Expositions, Boston, USA
  • March 2010 Pravin Bhansali, Viranga Tillekeratne. “Synthesis of the potent anticancer agent largazole and its analogs.” 239th ACS National Meeting and Expositions, San Francisco, USA
  • May 2009 Pravin Bhansali, Viranga Tillekeratne. “Synthesis of the potent anticancer agent largazole and its analogs.” 41st Central Regional Meeting of the American Chemical Society (CERMACS), Cleveland, USA

Oral Presentations

1) In USA

  • Sep 2014 “Synthesis and Biological Evaluations of Bioactive Compounds” Johns Hopkins University, Baltimore, MD, USA
  • Jul 2011 Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry, Pittsburgh, PA, USA
  • Jun 2011 “Synthesis and Biological Evaluation of Histone Deacetylase Inhibitor Largazole and Analogs” Presented at University of North Carolina, Chapel Hill, NC, USA
  • Jun 2011 “Synthesis and Biological Evaluation of Histone Deacetylase Inhibitor Largazole and Analogs” Dept. of Medicinal Chemistry, University of Toledo, OH, USA
  • Apr 2010 “Synthesis of largazole and its analogs” Dept. of Medicinal Chemistry, University of Toledo, OH, USA
  • Nov 2008 “Progress toward total synthesis of largazole” Department of Chemistry, University of Toledo, OH, USA
  • Nov 2008 “Synthetic strategies for largazole” Sigma Xi Conference, University of Toledo, OH, USA
  • May 2008 “Synthetic strategies for largazole” Grad. Students Assoc. Symposium, University of Toledo, OH, USA

2) In India

  • Sept 2019 “Higher USA educational opportunities for undergraduate students in India”, Rajesh
  • Bhaiyya Tope College of Pharmacy, Aurangabad, Maharashtra
  • Jan 2020 “Higher USA educational opportunities for undergraduate students in India”, Shrinath
  • College of Pharmacy, Aurangabad, Maharashtra
  • May 2021 “Higher USA educational opportunities for undergraduate students in India”, SVKM
  • Institute of Pharmacy, Dhule, Maharashtra
  • June 2021 “Invited talk at AICTE sponsored Short Term Training Program (STTP) at the R. C. Patel
  • Institute of Pharmaceutical Education and Research (RC PIPER), Shirpur, Maharashtra on
  • “Funding opportunities for fellowships, training, collaborations and higher education in USA
  • and other foreign countries”
  • SCOPUS ID 54400753400
  • WOS ID AAA-5946-2021
  • ORCID ID 0000-0003-1870-1852

US Patents:

  • Viranga Tillekeratne, Ayad Al-Hamashi, Jehad Almaliti, Pravin Bhansali, “HDAC inhibitors as anticancer agents” US Patent (United States Serial No. 9469656 Issue Date: October 18, 2016) http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9469656.PN.&OS=PN/9469656&RS=PN/9469656
  • Ronald E. Viola, Bharani Thangavelu, Mutthamsetty; Vinay, Wang; Qinzhe, Pravin Bhansali, “Potent phthalate inhibitors of aspartate N-acetyltransferase and selective aspartate pathway inhibitors” US Patent (United States Serial No. 10449168 Issue Date: October 22, 2019) http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=10449168.PN.&OS=PN/10449168&RS=PN/10449168